.
References that have been discarded to make way for new 'hits'
can be found here. If you're really that
interested, you
can download an Excel spreadsheet of all ICM Hit Parade
references, past and present, from this page here.©
James Austin 2003
Last updated 28 March 2009
The following ‘Top 100 references’ are based on no objective ranking whatsoever, but purely my subjective opinion as to what is topical or useful to know about for the DICM exam. Preference has been given to papers that have been asked in the actual exam (underlined); meta-analyses and systematic reviews; ‘household names’ in ICU literature; recent papers; and papers describing new drugs or forthcoming major studies. Low priority has been given to teaching reviews (with a few exceptions), animal or lab studies, and foreign-language or ‘minor’ journals. No attempt has been made to cover the realm of ICM literature evenly.
Feel free to disagree with my Hit Parade – I’d welcome any suggestions for items that should be included, emailed to austin@dicm.co.uk . Please include: enough detail to locate the reference; your reason why it should be in the Top 100; and (ideally) your vote for which of the existing entries to drop in place of the new candidate. I’ll do my best to update the list if and when anything ‘hot’ hits the journals, but no promises!
By
request, references that have been added in the most recent update
are now marked .
References that have been discarded to make way for new 'hits'
can be found here. If you're really that
interested, you
can download an Excel spreadsheet of all ICM Hit Parade
references, past and present, from this page here.
References are arranged by topic, rather than any hypothetical order of importance. Links are included to PubMed, and to free online full text where available.
Read this series of five articles from CCM before anything else! An excellent guide to critical analysis of journal stuff, as well as a practical critique of five useful papers. If you want more detail, JAMA has a similar series called Users’ Guide to Evidence-based Practice (link updated).
Cook DJ,
Hebert PC, Heyland DK, Guyatt GH, Brun-Buisson C et al.
How to use an article on therapy or prevention: pneumonia
prevention using subglottic secretion drainage.
Critical Care Medicine 1997; 25:
1502-1513.
PubMed Abstract
Jaeschke
RZ, Meade MO, Guyatt GH, Keenan SP, Cook DJ.
How to use diagnostic test articles in the intensive care unit:
diagnosing weanability using f/Vt.
Critical Care Medicine 1997; 25:
1514-1521.
PubMed Abstract
Meade MO,
Cook DJ, Kernerman P, Bernard G.
How to use articles about harm: the relationship between high
tidal volumes, ventilating pressures, and ventilator-induced lung
injury.
Critical Care Medicine 1997; 25:
1915-1922.
PubMed Abstract
Cook DJ,
Levy MM, Heyland DK.
How to use a review article: prophylactic endoscopic
sclerotherapy for esophageal varices.
Critical Care Medicine 1998; 26:
692-700.
PubMed Abstract
Keenan SP,
Guyatt GH, Sibbald WJ, Cook DJ, Heyland DK, Jaeschke RZ.
How to use articles about diagnostic technology: gastric
tonometry.
Critical Care Medicine 1999; 27:
1726-1731.
PubMed Abstract
National
Confidential Enquiry into Patient Outcome and Death
Trauma: Who cares?
NCEPOD 2007 Report
Who came up with that title?!
NCEPOD
downloads
Levy
MM, Rapoport J, Lemeshow S, Chalfin DB, Phillips G, Danis M.
Association between critical care physician management and patient
mortality in the intensive care unit.
Annals of Internal
Medicine 2008; 148:
801-9
Shock, horror and endless correspondence - "They
must have missed something!"
PubMed Abstract
AIM Full Text
Winters
BD, Pham JC, Hunt EA, Guallar E, Berenholtz S, Pronovost PJ.
Rapid response systems: a systematic review.
Critical Care Medicine 2007; 35:
1238-43
METs: do they work or don't they?
PubMed Abstract
Harrison
DA, Brady AR, Rowan K.
Case mix, outcome and length of stay for
admissions to adult, general critical care units in England,
Wales and Northern Ireland: the Intensive Care National Audit
& Research Centre Case Mix Programme Database.
Critical Care 2004; 8:
R99-111
Every British intensivist should know something about ICNARC!
OK, maybe not the Scots........
PubMed Abstract
Critical
Care Full Text
Priestap
FA, Martin CM.
Impact of intensive care unit discharge time on patient outcome.
Critical Care Medicine 2006; 34:
2946-51
Worried about pushing patients out at night to make beds?
Well, you should.........
PubMed Abstract
Taylor B, Kemp V, Goldhill D, Waldmann C
Critical care contingency planning: phased responses and triaging
framework.
Journal of the Intensive Care Society
2008: 9:
16-19
How will your
ICU respond when the
flu pandemic hits?
JICS Full Text
Eichacker
PQ, Gerstenberger EP, Banks SM, Cui X,
Natanson C
Meta-analysis of acute lung injury and acute respiratory distress
syndrome trials testing low tidal volumes.
American Journal of
Respiratory and
Critical Care Medicine 2002 166:1510-4.
A meta-analysis that explains why low-Vt works in some
studies (e.g. ARDSNET) and not others!
PubMed (no abstract available)
AJRCCM Full Text
Fernandez R, Trenchs X, Klamburg J, Castedo J, Serrano JM et al.
Prone positioning in acute respiratory distress syndrome: a multicenter
randomized clinical trial.
Intensive Care Medicine
2008; 34:
1487-91
Add to this not one, not two, but three meta-analyses in the three
months preceding this, and you have a cold topic getting hot again!
PubMed Abstract
Talmor D, Sarge T,
Malhotra A, O'Donnell CR, Ritz R
Mechanical ventilation guided by esophageal pressure in acute lung
injury.
New England Journal of
Medicine 2008: 359;
2095-10
Oh, so narrowly missed a
significant mortality benefit - why, oh why did they stop
early?
PubMed Abstract
Wiedemann
HP, Wheeler AP, Bernard GR, Thompson BT, Hayden D et al, for
ARDSNET
Comparison of two fluid-management strategies in acute lung
injury.
New England Journal of Medicine 2006; 354:
2564-75.
Read the editorial and
extensive
correspondence
as well
PubMed Abstract
NEJM Full Text
Girard
TD, Kress JP, Fuchs BD, Thomason JW, Schweickert WD et al.
Efficacy and safety of a paired sedation and ventilator weaning
protocol for mechanically ventilated patients in intensive care
(Awakening and Breathing Controlled trial): a randomised controlled
trial.
Lancet 2008; 371:
126-34.
NNT = 7.4 for mortality!
PubMed Abstract
Burns KE,
Adhikari NK, Meade MO.
A meta-analysis of noninvasive weaning to facilitate liberation
from mechanical ventilation.
Canadian Journal of Anaesthesia 2006; 53:
305-15.
Can't get them off the ventilator? Just extubate to mask
BiPAP
PubMed Abstract
CJA Full Text
Cochrane Full Text
Esteban A,
Frutos-Vivar F, Ferguson ND, Arabi Y, Apezteguia C et al.
Noninvasive positive-pressure ventilation
for
respiratory failure after extubation.
New England
Journal of Medicine
2004; 350: 2542-2560
......But it's no good waiting for respiratory failure to set
in - NIV too late only makes things worse!
PubMed Abstract
NEJM Full Text
Peter JV,
Moran JL, Phillips-Hughes J, Graham P, Bersten AD.
Effect of non-invasive positive pressure ventilation (NIPPV) on
mortality in patients with acute cardiogenic pulmonary oedema: a
meta-analysis.
Lancet 2006; 367: 1155-63.
Hmmm.... I think I'd rather have the CPAP than the BiPAP,
thanks
PubMed Abstract
Adhikari
NK, Burns KE, Friedrich JO, Granton JT, Cook DJ, Meade MO.
Effect of nitric oxide on oxygenation and mortality in acute lung
injury: systematic review and meta-analysis.
British Medical Journal 2007; 334:
779-86
A disappointing performance from 1992's Molecule Of The Year
PubMed Abstract
BMJ Full Text
Meduri GU, Marik PE,
Chrousos GP, Pastores SM, Arlt W et al.
Steroid treatment in ARDS: a critical appraisal of the ARDS network
trial and the recent literature.
Intensive Care Medicine
2008; 34:
61-9
Meduri tells them how it
should be done.....
PubMed Abstract
Peter JV, John P,
Graham PL, Moran JL, George IA, Bersten A
Corticosteroids in the prevention and treatment of acute respiratory
distress syndrome (ARDS) in adults: meta-analysis.
British Medical Journal
2008; 336:
1006-9.
And after three rounds
of Meduri vs ARDS-NET, it's .... too close to call!
PubMed Abstract
BMJ Full Text
Salluh JI, Póvoa P,
Soares M, Castro-Faria-Neto HC, Bozza FA, Bozza PT
The role of corticosteroids in severe community-acquired pneumonia: a
systematic review.
Critical Care
2008; 12:
R76
A fairly luke-warm
conclusion for what seemed like very positive findings?
PubMed Abstract
Critical
Care Full Text
Fan T, Wang G, Mao B, Xiong Z, Zhang Y, Liu X, Wang L, Yang S
Prophylactic
administration of parenteral steroids for preventing airway
complications after extubation in adults: meta-analysis of randomised
placebo controlled trials.
British Medical Journal
2008; 337:
1088-91
More steroids, anyone? A
medical student provides the decider in Roberts et al vs the Cochrane Review......
PubMed Abstract
BMJ Full Text
Canadian
Critical Care Trials Group; Heyland D, Dodek P, Muscedere J, Day
A.
A randomized trial of diagnostic techniques for
ventilator-associated pneumonia.
New England Journal of Medicine 2006; 355:
2619-30
How you diagnose it makes no difference...............
PubMed Abstract
NEJM Full Text
Safdar N,
Dezfulian C, Collard HR, Saint S
Clinical and economic consequences of ventilator-associated
pneumonia: a systematic review.
Critical Care Medicine 2005; 33:
2184-93.
........ but actually having it certainly does!
PubMed Abstract
Blot F, Similowski T, Trouillet JL, Chardon P, Korach JM et al.
Early tracheotomy versus prolonged endotracheal intubation in
unselected severely ill ICU patients.
Intensive Care Medicine
2008; 34:
1779-87
Blot et al. stealing a
march on TracMan
PubMed Abstract
Colebourn
CL, Barber V, Young JD.
Use of helium-oxygen mixture in adult patients presenting with
exacerbations of asthma and chronic obstructive pulmonary
disease: a systematic review.
Anaesthesia 2007; 62: 34-42.
Heliox: it's good (but not VERY good).............
PubMed Abstract
Chalwin
RP, Moran JL, Graham PL.
The role of extracorporeal membrane oxygenation for treatment of the
adult respiratory distress syndrome: review and quantitative analysis.
Anaesthesia and Intensive Care 2008; 36:
152-61.
We're still waiting in suspense for CESAR to get published -
but here's a sneak peek...
PubMed Abstract
Müller T, Lubnow M, Philipp A, Bein T, Jeron A et
al.
Extracorporeal pumpless interventional lung assist in clinical
practice: determinants of efficacy.
European Respiratory
Journal 2009;
33: 551-8
And now: pocket ECMO!
(no batteries required)
PubMed Abstract
Shah MR,
Hasselblad V, Stevenson LW, Binanay C, O'Connor CM et al.
Impact of the pulmonary artery catheter in critically ill
patients: meta-analysis of randomized clinical trials.
Journal of the American Medical Association
2005; 294; 1664-70
Bottom line: it doesn't kill people, and it doesn't help
either.....
PubMed Abstract
JAMA Full Text (free but requires
registration)
Rivers
E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B et al.
Early goal-directed therapy in the treatment of severe sepsis
and septic shock.
New England Journal of Medicine
2001; 345:
1368-1377.
Goal-directed therapy does work, if you
hit them soon
enough............
PubMed Abstract
NEJM Full Text
Jones
AE, Brown MD,
Trzeciak S, Shapiro NI, Garrett JS et al.; Emergency Medicine
Shock Research Network
The
effect of a quantitative resuscitation strategy on mortality in
patients with sepsis: a meta-analysis.
Critical Care Medicine
2008; 36:
2934-9
Like the Daddy of
goal-directed therapy said before: it only works if you hit
'em early!
PubMed Abstract
Leone M, Martin C.
Vasopressor use in septic shock: an update.
Current Opinion in Anaesthesiology 2008; 21:
141-7.
So we still
don't know which inotrope to use....
PubMed Abstract
Póvoa
PR, Carneiro AH, Ribeiro OS, Pereira AC; on behalf of the Portuguese
Community-Acquired
Sepsis Study Group.
Influence
of vasopressor agent in septic shock mortality. Results from the
Portuguese Community-Acquired Sepsis Study (SACiUCI study).
Critical Care Medicine 2009;
37: 410-416
... but maybe it shouldn't be noradrenaline...?
PubMed Abstract
Russell JA, Walley KR, Singer J, Gordon AC, Hébert PC et al.: the VASST
Investigators
Vasopressin versus norepinephrine infusion in patients with septic
shock.
New England Journal of Medicine 2008; 358:
877-87.
It's here, it's VASST, it's ... a bit inconclusive, really
PubMed Abstract
NEJM Full Text
Gheorghiade
M, Konstam MA, Burnett JC Jr, Grinfeld L, Maggioni AP, et al.
(EVEREST Investigators).
Short-term clinical effects of tolvaptan, an oral vasopressin
antagonist, in patients hospitalized for heart failure: the
EVEREST Clinical Status Trials.
Journal of the American Medical Association
2007; 297: 1332-43
Encouraging - but what about the real outcomes.............?
PubMed Abstract
JAMA Full Text
Topol EJ.
Nesiritide - not verified.
New England Journal of Medicine 2005; 353:
113-6.
The forthcoming ETNA trial
could determine
whether Nesiritide makes it into Europe - or will ASCEND get there first?.
PubMed (no abstract)
NEJM Full Text
The SAFE
Study Investigators
A comparison of albumin and saline for fluid resuscitation in the
intensive care unit.
New England Journal of Medicine 2004; 350:
2247-2256
"See? Told you albumin was safe!" "See?
Told you it was no better than crystalloid!"
PubMed Abstract
NEJM Full Text
Vincent
JL, Sakr Y, Reinhart K, Sprung CL, Gerlach H, Ranieri VM; the
'Sepsis Occurrence in Acutely Ill Patients' investigators
Is albumin administration in the acutely ill associated with
increased mortality? Results of the SOAP study.
Critical Care 2005; 9: R745-54.
Albumin: SAFE as SOAP?
PubMed Abstract
Critical
Care Full Text
Walsh
TS,
Saleh EE.
Anaemia during critical illness.
British Journal of Anaesthesia 2006; 97:
278-291
An excellent review of a core DICM exam topic
PubMed Abstract
BJA Full Text
Marik
PE, Corwin HL.
Efficacy of red blood cell transfusion in the critically ill: a
systematic review of the literature.
Critical Care Medicine
2008; 36:
2667-74
A massive cohort
meta-analysis to back up the findings of the TRICC Study
PubMed Abstract
Aronson D, Dann EJ, Bonstein L, Blich M, Kapeliovich M et al.
Impact of red blood cell transfusion on clinical outcomes in patients
with acute myocardial infarction.
American Journal of
Cardiology 2008; 102:
115-9
Isn't it funny how
someone always publishes a key paper just a couple of months after
someone else does a comprehensive review?
PubMed Abstract
Marik
PE, Corwin HL.
Acute lung injury following blood transfusion: expanding the definition.
Critical Care Medicine
2008; 36:
3080-4
An up-to-date review of
a popular exam topic
PubMed
Abstract
Heyland
DK, Dhaliwal R, Drover JW, Gramlich L, Dodek P; Canadian Critical
Care Clinical Practice Guidelines Committee.
Canadian clinical practice guidelines for
nutrition support in mechanically ventilated, critically ill
adult patients.
Journal of Parenteral and Enteral Nutrition
2003; 27: 355-73
Everything you ever wanted to know about ICU nutrition, with
an evidence base!
PubMed Abstract
Simpson
F,
Doig GS.
Parenteral vs. enteral nutrition in the critically ill patient: a
meta-analysis of trials using the intention to treat principle.
Intensive Care Medicine 2005; 31:
12-23.
TPN is better. Better than enteral nutrition, or better than
nothing?
PubMed Abstract
Petrov
MS, van
Santvoort HC, Besselink MG, van der Heijden GJ, Windsor JA, Gooszen HG.
Enteral
nutrition and the risk of mortality and infectious complications in
patients with severe acute pancreatitis: a meta-analysis of randomized
trials.
Archives of Surgery
2008; 143: 1111-7
At last - the surgeons
leading the way in feeding pancreatitis patients!
PubMed Abstract
Marik
PE, Zaloga GP.
Immunonutrition in critically ill patients: a systematic review and
analysis of the literature.
Intensive Care Medicine
2008; 34:
1980-90
State-of-the-art, from
an immunonutrition enthusiast
PubMed Abstract
Pontes-Arruda
A,
Demichele S, Seth A, Singer P.
The
use of an inflammation-modulating diet in patients with acute lung
injury or acute respiratory distress syndrome: a meta-analysis of
outcome data.
Journal of Parenteral and
Enteral Nutrition 2008; 32: 596-605
Break out the Oxepa!
PubMed Abstract
Angstwurm
MW, Engelmann L, Zimmermann T, Lehmann C, Spes CH, Abel P et al.
Selenium in Intensive Care (SIC): results of a prospective
randomized, placebo-controlled, multiple-center study in patients
with severe systemic inflammatory response syndrome, sepsis, and
septic shock.
Critical Care Medicine 2007; 35:
118-26
Another win for anti-oxidants...........
PubMed Abstract
Pronovost
P, Needham D, Berenholtz S, Sinopoli D, Chu H, Cosgrove S et al.
An intervention to decrease catheter-related bloodstream
infections in the ICU.
New England Journal of Medicine 2006; 355:
2725-32.
Wow. Why would implementing good aseptic technique cause such
an ethical controversy?
PubMed Abstract
NEJM Full Text
Watkinson
PJ, Barber VS, Dark P, Young JD.
The use of pre-, pro- and synbiotics in adult intensive care unit
patients: Systematic review.
Clinical Nutrition 2007; 26:
182-92
No more yoghurt for you, Mrs Robinson.................
PubMed Abstract
Shittu
A,
Lin J
Newer anti-staphylococcal agents: in-vitro studies and emerging
trends in Staphylococcus aureus resistance
Wounds 2006; 18:
129-146
New antibiotics coming soon to an ICU near you - but how long
until that devious Staph finds a new anti-antibiotic?
Wounds Full Text
Playford
EG, Webster AC, Sorrell TC, Craig JC.
Antifungal agents for preventing fungal infections in
non-neutropenic critically ill and surgical patients: systematic
review and meta-analysis of randomized clinical trials.
Journal of Antimicrobial Chemotherapy 2006;
57:
628-38
Add to that not one
but two
meta-analyses on (nearly)
the same subject from CCM, and you have a hot
topic...........
PubMed Abstract
Cochrane Full Text
Huang L,
Quartin A, Jones D, Havlir DV.
Intensive care of patients with HIV infection.
New England Journal of Medicine 2006; 355:
173-81.
A 'hot topic' from the 2006 exam - two months before this
review came out!
PubMed (no abstract)
NEJM Full Text
Eichacker
PQ, Natanson C.
Increasing evidence that the risks of rhAPC may outweigh its
benefits.
Intensive Care Medicine 2007; 33:
396-9
After disappointing results from ADDRESS,
ENHANCE
and RESOLVE,
is the tide turning
against APC........?
PubMed (no abstract)
Friedrich
JO, Adhikari N, Herridge MS, Beyene J.
Meta-analysis: low-dose dopamine increases urine output but does
not prevent renal dysfunction or death.
Annals of Internal Medicine 2005; 142:
510-24
Is this the final, final
nail in the
coffin of renal-dose dopamine?
PubMed Abstract
AIM Full Text
Morelli
A,
Ricci Z, Bellomo R, Ronco C, Rocco M, Conti G et al.
Prophylactic fenoldopam for renal protection in sepsis: a
randomized, double-blind, placebo-controlled pilot trial.
Critical Care Medicine 2005; 33:
2451-6.
Is this the new renal dopamine? Not only does it reduce renal
failure, it may even improve mortality...
PubMed Abstract
Ho KM,
Sheridan DJ.
Meta-analysis of frusemide to prevent or treat acute renal
failure.
British Medical Journal 2006; 333:
420
- 425
Treating oliguria with frusemide is like - um - p---ing in
the wind.....?
PubMed Abstract
BMJ Full Text
Edwards
P,
Arango M, Balica L, Cottingham R, El-Sayed H, Farrell B,
Fernandes J et al. CRASH trial collaborators.
Final results of MRC CRASH, a randomised placebo-controlled trial
of intravenous corticosteroid in adults with head injury-outcomes
at 6 months.
Lancet. 2005; 365: 1957-9.
Oh well, that answers that one then........... now for CRASH
2
PubMed Abstract
Mauritz
W, Steltzer
H, Bauer P, Dolanski-Aghamanoukjan L, Metnitz P
Monitoring of intracranial pressure in patients with severe traumatic
brain injury: an Austrian prospective multicenter study.
Intensive Care Medicine
2008; 34:
1208-15
More (circumstantial)
evidence that ICP monitoring does not help improve outcome - but don't let that stop you!
PubMed Abstract
Tisdall
MM, Smith M.
Cerebral microdialysis: research technique or clinical tool.
British Journal of Anaesthesia 2006; 97:
18-25
Is this the monitoring of the future? (and it's not just for brains.....)
PubMed Abstract
BJA Full Text
Grande
PO.
The "Lund Concept" for the treatment of severe head
trauma - physiological principles and clinical application.
Intensive Care Medicine 2006; 32:
1475-84.
A sudden burst of journal interest in the Lund Concept
- but still no RCT...............?
PubMed Abstract
Nolan J
and Baskett P
European Resuscitation Council Guidelines for Resuscitation 2005
Resuscitation 2005; 67: Supplement
1
For the process and evidence behind the current guidelines
(CoSTR), see Volume 67 (2-3) of the same journal
Resuscitation TOC
ERC summary (changes only)
ERC
full guidelines (3.92MB pdf)
Download any or all of the above in bite-sized chunks from the ERC page
Böttiger
BW, Arntz HR, Chamberlain DA, Bluhmki E, Belmans A,
et al.; TROICA Trial Investigators
Thrombolysis during resuscitation for out-of-hospital cardiac arrest.
New England Journal of
Medicine 2008; 359:
2651-62
The long-awaited TROICA
Trial - what an anti-climax!
PubMed Abstract
Calandra
T, Cohen J; International Sepsis Forum Definition of Infection in
the ICU Consensus Conference.
The international sepsis forum consensus conference on
definitions of infection in the intensive care unit.
Critical Care Medicine 2005; 33:
1538-48.
Know these definitions by heart!
PubMed Abstract
Tan T, Brett S, Stokes T on behalf of the Guidelines Development Group.
Rehabilitation after critical illness: summary of NICE guidance.
British Medical Journal 2009; 338:
767-9
There's life after ICU.......
PubMed (no abstract)
Cheatham ML, Malbrain
ML, Kirkpatrick A, Sugrue M, Parr M, De Waele J et
al.
Results from the International Conference of Experts on
Intra-abdominal Hypertension and Abdominal Compartment Syndrome.
II. Recommendations.
Intensive Care Medicine 2007; 33: 951-62
A sequel to this one...
PubMed Abstract
Riker RR, Shehabi Y, Bokesch PM, Ceraso D, Wisemandle W et al. for the
SEDCOM Study Group
Dexmedetomidine vs midazolam for sedation of critically ill patients: a
randomized trial.
Journal of the American
Medical Association 2009; 301: 489-99
Less delirium, less
ventilator time, shorter ICU stay? Make it so!
PubMed Abstract
Hassanein
TI, Tofteng
F, Brown RS Jr, McGuire B, Lynch P et al.
Randomized controlled study of extracorporeal albumin dialysis for
hepatic encephalopathy in advanced cirrhosis.
Hepatology
2007; 46:
1853-62.
... and a pretty strong
trend towards improved survival - in the short term, at least....
PubMed Abstract
Hepatology Full Text
Stravitz
RT, Kramer
AH, Davern T, Shaikh AO, Caldwell SH et al.
Intensive care of patients with acute liver failure: recommendations of
the U.S. Acute Liver Failure Study Group.
Critical Care Medicine
2007; 35:
2498-508
Fancy managing the
coagulation of a hypothermic liver failure patient for transplantation?
Pubmed
Abstract
Spahn
DR,
Cerny V, Coats TJ, Duranteau J, Fernandez-Mondejar E, Gordini G
et al.
Management of bleeding following major trauma: a European
guideline.
Critical Care 2007; 11: R17
Forget Factor VIIa - control the bleeding fast!
PubMed Abstract
Critical
Care Full Text
Pawar
KS,
Bhoite RR, Pillay CP, Chavan SC, Malshikare DS, Garad SG.
Continuous pralidoxime infusion versus repeated bolus injection
to treat organophosphorus pesticide poisoning: a randomised
controlled trial.
Lancet 2006; 368:
2136-41
Following so soon after Peter's meta-analysis,
could
this be a new Hot Topic.........?
PubMed Abstract
Lin MT,
Albertson TE
Genomic polymorphisms in sepsis
Critical Care Medicine 2004; 32:
569-579
If molecular medicine is The Future, then here's your
horoscope.........
PubMed Abstract
Munger
MA.
New agents for managing hyponatremia in hospitalized patients.
American Journal of Health-System Pharmacy
2007:
64: 253-65
Remember the EVEREST
studies?
Well, here's another
use for AVP-antagonists!
PubMed Abstract
Arabi
Y, Gomersall CD, Ahmed QA, Boynton BR, Memish ZA.
The critically ill avian influenza A (H5N1) patient.
Critical Care Medicine 2007; 35:
1397-403
Still a potential hot topic...........
PubMed Abstract
If, after all that, you still haven't had enough of ICM literature, then you are a 'journal junkie'. For a further fix, see:
Baltussen
A, Kindler CH
Citation classics in critical care medicine
Intensive Care Medicine 2004; 30:
902-910
This is a list of the most-cited articles in both the
critical care literature, and general medical literature relevant
to critical care. The authors also provide some analytic
statistics, and a discussion of the utility of 'citation
ranking'. Should you try and read all these papers for the DICM
as well (there are 119 in total, although of course several of
them also appear above)? I would argue not: the most-cited papers
are not necessarily the ones that you are most likely to be asked
about. In particular, recent 'hot topics' will not yet have
accumulated many citations; while many older papers have become
such basic knowledge in intensive care that reading the original
description is likely to be of historical interest only. Of note
is that 11 of the 15 most-cited papers in the critical care
literature are about scoring systems - presumably every time
someone uses a scoring system in their study, the original paper
picks up another citation. But do by all means read the paper
itself; and the list of most-cited papers is available below as a
Word document.
PubMed Abstract
Citation List
Finally, for a bit of light entertainment, try:
Bartlett
RH.
Alice in intensiveland. Being an essay on nonsense and common
sense in the ICU, after the manner of Lewis Carroll.
Chest 1995; 108: 1129-39.
Of course, none of us would do anything that silly, would we?
Like giving frusemide for oliguria, or subtracting the PEEP from
the CVP.........
PubMed (no abstract)
Chest Full Text